• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文OA文献 >Studies in fetal wound healing. IV. Hyaluronic acid-stimulating activity distinguishes fetal wound fluid from adult wound fluid.
【2h】

Studies in fetal wound healing. IV. Hyaluronic acid-stimulating activity distinguishes fetal wound fluid from adult wound fluid.

机译：胎儿伤口愈合的研究。 IV。透明质酸刺激活性将胎儿伤口液与成人伤口液区分开。

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Recent clinical and experimental evidence suggests that the fetus responds to injury in a fashion fundamentally different from that of the adult. Our initial experience with human open fetal surgery reinforces experimental observations that the fetal wounds heal without the scarring, inflammation, and contraction that often accompany adult wounds. In this study we examine fetal wound fluid in an attempt to elucidate the control mechanisms that endow the fetus with unique healing properties. The extracellular matrix of fetal wounds is rich in hyaluronic acid, a glycosaminoglycan found in high concentrations whenever there is tissue proliferation, regeneration, and repair. We establish that wound fluid from the fetus contains high levels of hyaluronic acid-stimulating activity that may underlie the elevated deposition of hyaluronic acid in the fetal wound matrix. In contrast there was no hyaluronic acid-stimulating activity present in adult wound fluid. Hyaluronic acid, in turn, fosters an extracellular environment permissive for cell motility and proliferation that may account for the unique properties observed in fetal wound healing.
机译：最近的临床和实验证据表明，胎儿对损伤的反应方式与成年人完全不同。我们在人类开放式胎儿外科手术方面的初步经验加强了实验观察，即胎儿伤口愈合时没有成人伤口常伴有的疤痕，炎症和收缩。在这项研究中，我们研究了胎儿创面液，试图阐明赋予胎儿独特治疗特性的控制机制。胎儿伤口的细胞外基质富含透明质酸，透明质酸是一种糖胺聚糖，在组织增殖，再生和修复时会以高浓度存在。我们确定来自胎儿的伤口液含有高水平的透明质酸刺激活性，这可能是透明质酸在胎儿伤口基质中升高沉积的基础。相反，在成人伤口液中不存在透明质酸刺激活性。透明质酸反过来促进了允许细胞运动和增殖的细胞外环境，这可能解释了胎儿伤口愈合中观察到的独特特性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号